Three best friends, Romano, Pencil and The Pope rise quickly through the criminal underworld to take control of Amsterdam’s cocaine trade. However, jealously tears their friendship apart and they become enemies. The Pope joins up with his old school friend, Tatta, and goes into battle against Romano and Pencil. Unfortunately, his attempt to rip off Romano over a coke deal goes horribly wrong and two of his gang are killed. The Pope takes a gruesome revenge which ignites a long-running gang war and brings violence and death to the streets of Amsterdam.

After breaking out of prison, Romano is on the run, but remains in Amsterdam. His friends Pencil and Adil try to convince him to flee the country, but Romano refuses and promises he won’t leave without Celine – who still wants to divorce him – and his daughter Elvira. It’s a promise he must break once investigative journalist Rein discovers his hiding place. With Pencil and fellow prison breakout Eiffel, Romano flees to Ojèn, near Marbella. Here they plan their next move in their war with Pope only to find themselves dragged into an Irish gang war.